Moderator
Ru-Rong Ji, PhD
Duke University Medical Center
US
Webinar attendees will be able to submit questions during a Q & A period after the talk. You can also submit questions now, by emailing them to neil.andrews@iasp-pain.org.
Mitochondria are one of the important intracellular organelles responsive to the production of ATP. Mitochondria exist abundantly in neuronal cells as an energy source of neuronal activity, such as synaptic transmission, axonal transport, and protein synthesis. Mitochondrial quality is tightly regulated by the autophagocytosis of damaged mitochondria. Disruption of mitochondrial quality control is a common pathological change observed in diabetes and neurodegenerative diseases. Dr. Amaya will demonstrate the biological significance of mitochondrial dysfunction in DRG neurons and its association with the development of painful diabetic neuropathy. He will highlight the role of p53 and parkin for the regulation of mitochondrial quality control.
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